Issue 24, 2001
From the journal:

Chemical Communications

Pseudoxazolones, a new class of inhibitors for cysteine proteinases: inhibition of hepatitis A virus and human rhinovirus 3C proteinases

Yeeman K. Ramtohul,a   Nathaniel I. Martin,a   Lara Silkin,a   Michael N. G. James†b  and  John C. Vederas‡*a  

* Corresponding authors

a Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada
E-mail: john.vederas@ualberta.ca;
Fax: +1 (780) 492 8231;
Tel: +1 (780) 492 5475

b Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
E-mail: michael.james@ualberta.ca;
Fax: +1 (780) 492 0886;
Tel: +1 (780) 492 4550

Abstract

Monophenyl and diphenyl pseudoxazolone derivatives of glycine and alanine were prepared and found to be time-dependent inhibitors of hepatitis A virus (HAV) 3C and human rhinovirus (HRV) 3C proteinases with IC50 values in the micromolar range.

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Article information

DOI
https://doi.org/10.1039/B109095J
Article type
Communication
Submitted
09 Oct 2001
Accepted
14 Nov 2001
First published
06 Dec 2001

Chem. Commun., 2001, 2740-2741

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Pseudoxazolones, a new class of inhibitors for cysteine proteinases: inhibition of hepatitis A virus and human rhinovirus 3C proteinases

Y. K. Ramtohul, N. I. Martin, L. Silkin, M. N. G. James and J. C. Vederas, Chem. Commun., 2001, 2740 DOI: 10.1039/B109095J

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