Issue 24, 2001
From the journal:

Chemical Communications

Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst: access to enantiopure cyclic cis-amino alcohols†

Takeo Kawabata,*a   Kensaku Yamamoto,a   Yashima Momose,a   Hiroshi Yoshida,a   Yoshie Nagaokaa  and  Kaoru Fujia  

* Corresponding authors

a Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan
E-mail: kawabata@scl.kyoto-u.ac.jp

Abstract

Acylative kinetic resolution of racemic cyclic cis-amino alcohol derivatives with a chiral nucleophilic catalyst proceeds enantioselectively (s = 10–21) at ambient temperature to give enantiopure recovered materials, and the % conversion of the acylation can be readily controlled by the amount of acid anhydride.

Graphical abstract: Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst: access to enantiopure cyclic cis-amino alcohols

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Article information

DOI
https://doi.org/10.1039/B108753C
Article type
Communication
Submitted
27 Sep 2001
Accepted
01 Nov 2001
First published
27 Nov 2001

Chem. Commun., 2001, 2700-2701

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Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst: access to enantiopure cyclic cis-amino alcohols

T. Kawabata, K. Yamamoto, Y. Momose, H. Yoshida, Y. Nagaoka and K. Fuji, Chem. Commun., 2001, 2700 DOI: 10.1039/B108753C

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