Issue 16, 2001
From the journal:

Chemical Communications

Antisense molecules and furanose conformations—is it really that simple?

Lisbet Kværnø†a  and  Jesper Wengel*b  

* Corresponding authors

a Center for Synthetic Bioorganic Chemistry, Department of Chemistry, University of Copenhagen, Universitetsparken 5, Copenhagen, Denmark

b Department of Chemistry, University of Southern Denmark, Campusvej 55, Denmark.
E-mail: jwe@chem.sdu.dk;
Fax: +45 66 15 87 80

Abstract

Selected nucleic acid mimics are discussed in the context of the antisense therapeutic strategy with focus on furanose conformation, RNA-binding affinity, and activation of the RNA-cleaving enzyme RNase H.

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Article information

DOI
https://doi.org/10.1039/B104605P
Article type
Feature Article
Submitted
25 May 2001
Accepted
13 Jun 2001
First published
26 Jul 2001

Chem. Commun., 2001, 1419-1424

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Antisense molecules and furanose conformations—is it really that simple?

L. Kværnø and J. Wengel, Chem. Commun., 2001, 1419 DOI: 10.1039/B104605P

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