Kröhnke type pyridines are readily accessible via a sequential solventless aldol condensation and Michael addition involving solid NaOH, followed by treatment with ammonium acetate in acetic acid, as a one pot reaction, which enables both symmetrical and unsymmetrical 2,6-bisaryl substituted pyridines to be isolated in high yield, typically >75%.
Toward benign syntheses of pyridines involving sequential solvent free aldol and Michael addition reactions
G. W. V. Cave and C. L. Raston, Chem. Commun., 2000, 2199 DOI: 10.1039/B007431O
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