Issue 16, 2000
From the journal:

Chemical Communications

The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess

Kaori Matoishi,a   Satoshi Hanzawa,b   Hitoshi Kakidani,a   Masumi Suzuki,a   Takeshi Sugaia  and  Hiromichi Ohta*a  

* Corresponding authors

a Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Japan.
E-mail: hohta@chem.keio.ac.jp

b Tokyo Research Center, Tosoh Corp., 2743-1 Hayakawa, Ayase, Japan.

Abstract

Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation followed by enantioface-differentiating protonation of [α-2H]- and [α-1H]phenylmalonic acid in 1H2O and 2H2O respectively, gave highly enantiomerically enriched (R)- and (S)-[α-2H]phenylacetic acid in quantitative yields.

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Article information

DOI
https://doi.org/10.1039/B003941L
Article type
Communication
Submitted
17 May 2000
Accepted
30 Jun 2000
First published
21 Jul 2000

Chem. Commun., 2000, 1519-1520

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The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess

K. Matoishi, S. Hanzawa, H. Kakidani, M. Suzuki, T. Sugai and H. Ohta, Chem. Commun., 2000, 1519 DOI: 10.1039/B003941L

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