The reaction of amidines with α-amino acid alkynyl ketones is shown to be a versatile route to pyrimidin-4-yl substituted α-amino acids. This route is also applicable to a parallel synthesis approach and has allowed the formation of a range of pyrimidin-4-yl substituted α-amino acids, including the naturally occurring α-amino acid L-lathyrine 4.
R. M. Adlington, J. E. Baldwin, D. Catterick and G. J. Pritchard, J. Chem. Soc., Perkin Trans. 1, 1999, 855 DOI: 10.1039/A806741D
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