Enantioselective synthesis of epoxides and aziridines by asymmetric methylidene transfer from a sulfimide to carbonyl compounds and imines

Abstract

The sodium salt of sulfimide 2 is a useful asymmetric methylidene transfer agent for the synthesis of enantiomerically enriched epoxides and aziridines. Moderate enantioselectivities are observed with a broad range of carbonyl compounds and with imines. An enantiomerically enriched β-adrenoreceptor agonist analogue was prepared using the new method.