Synthesis based on cyclohexadienes. Part 23.1 Total synthesis of 5-epi-pupukean-2-one
Abstract
A new strategy for the construction of the isotwistane skeleton is reported from easily available cyclohexadienes which involves stereoselective alkylation of a bicyclooctenone derivative and a decarboxylative 5-exo-trig radical cyclisation as the key steps in the total synthesis of 5-epi-pupukean-2-one.