Medium-sized Cyclophanes. Part 44.1 Synthesis and Stereochemical Assignments of 9-Substituted 2,11-Dithia[3.3]metacyclophanes

Abstract

Various syn- and anti-9-substituted 2,11-dithia[3.3]metacyclophanes are obtained by the coupling reaction of the corresponding 2,6-bis(bromomethyl)benzenes and 1-substituted 2,6-bis(sulfanylmethyl)-4-tert-butylbenzenes under highly diluted conditions in 10% ethanolic KOH in the presence of a small amount of NaBH ₄ .