Deoxyribonucleic acid binding and photocleavage studies of rhenium(I) dipyridophenazine complexes
Abstract
The intercalative binding interaction of
[Re(dppz)(CO)
3
(py)][O
3
SCF
3
]
(dppz = dipyrido[3,2-a
:2′
,3′-c]phenazine, py = pyridine) and
[Re(dppn)(CO)
3
(py)][O
3
SCF
3
]
(dppn = benzo[i]dipyrido[3,2-a
:2′,3′-c]phenazine) with double-stranded
calf thymus DNA, and synthetic oligonucleotides poly(dA)·poly(dT)
and poly(dC)·poly(dG) has been studied with spectroscopic
methods. The complexes have been found to promote cleavage of plasmid
pBR322 DNA from the supercoiled form I to the open circular form II upon
irradiation. The crystal structure of
[Re(dppz)(CO)
3
(py)][O
3
SCF
3
] has also
been established.
:2′
,3′-c]phenazine, py = pyridine) and
[Re(dppn)(CO)
3
(py)][O
3
SCF
3
]
(dppn = benzo[i]dipyrido[3,2-a
:2′,3′-c]phenazine) with double-stranded
calf thymus DNA, and synthetic oligonucleotides poly(dA)·poly(dT)
and poly(dC)·poly(dG) has been studied with spectroscopic
methods. The complexes have been found to promote cleavage of plasmid
pBR322 DNA from the supercoiled form I to the open circular form II upon
irradiation. The crystal structure of
[Re(dppz)(CO)
3
(py)][O
3
SCF
3
] has also
been established.
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