Molecular modelling comparisons of several known natural and synthetic inhibitors of electron transport, e.g. rotenone, papaverine, and piericidin A, suggested new ‘hybrid’ structures 8–12, and relatives, as potential new inhibitors. Synthetic routes to these targets, some of which display significant biological activity, are outlined.
G. S. Cockerill, P. C. Levett and D. A. Whiting, J. Chem. Soc., Perkin Trans. 1, 1995, 1103 DOI: 10.1039/P19950001103
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