Issue 5, 1995

Synthesis of water-soluble sugar derivatives of combretastatin A-4

Abstract

Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1995, 577-581

Synthesis of water-soluble sugar derivatives of combretastatin A-4

R. T. Brown, B. W. Fox, J. A. Hadfield, A. T. McGown, S. P. Mayalarp, G. R. Pettit and J. A. Woods, J. Chem. Soc., Perkin Trans. 1, 1995, 577 DOI: 10.1039/P19950000577

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