The utility of the palladium(0) catalysed reaction of the serine-derived organozinc reagent 6 with functionalized aryl iodides, under a carbon monoxide atmosphere, to give protected 4-aryl-4-oxo α-amino acids 8 is illustrated by a short synthesis of L-kynurenine.
R. F. W. Jackson, D. Turner and M. H. Block, J. Chem. Soc., Chem. Commun., 1995, 2207 DOI: 10.1039/C39950002207
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