Issue 19, 1995

A new synthesis of aliphatic isothiocyanates from primary amines, convenient for in situ use

Abstract

Primary aliphatic amines react with carbon disulfide in the presence of BOP (benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate 1, giving the corresponding isothiocyanates in good to high yields and high purity; a number of isothiocyanates are synthesized and isolated or generated in situ and treated with a nucleophile.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 1995-1996

A new synthesis of aliphatic isothiocyanates from primary amines, convenient for in situ use

U. Boas and M. H. Jakobsen, J. Chem. Soc., Chem. Commun., 1995, 1995 DOI: 10.1039/C39950001995

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