The stereoselective reduction and conformational analysis of 11-oxo-13-tetradecanolide
Abstract
11-Oxo-13-tetradecanolide was synthesized by the lactonization of the corresponding thioketal of 11-oxo-13-hydroxytetradecanoic acid; after hydrolysis of the thioketal, the resulting ketone was reduced in 62% yield with >99.8% stereoselectivity.