Whole cell catalysed kinetic resolution of 6-azabicyclo[3.2.0]hept-3-en-7-one: synthesis of (–)-cispentacin (FR 109615)
Abstract
Enantioselective hydrolysis of the β-lactam (±)-2 using Rhodococcus equi provided (1R,5S)-6azabicyclo[3.2.0] hept-3-en-7-one (+)-2, a precursor of the antifungal agent cispentacin.