Enantiocontrolled reduction of prochiral aromatic ketones with borane using diastereoisomeric secondary aminoalcohols as chiral catalysts
Abstract
Exo- and endo-2-hydroxy-3-(1-methyl-2-pyrrolyl)methylaminobornanes were found to be efficient catalysts for enantioselective borane reduction of prochiral aromatic ketones with predictable absolute stereochemistry.