R-(+)-α-Lipoic acid (1), [α]D+107°, has been prepared in a six-step enantioselective synthesis from 6-bromohex-1-ene; the enantioselectivity is controlled by a Sharpless asymmetric epoxidation of the intermediate allyl alcohol (2).
P. C. B. Page, C. M. Rayner and I. O. Sutherland, J. Chem. Soc., Perkin Trans. 1, 1990, 1615 DOI: 10.1039/P19900001615
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