Issue 9, 1990

A new NAD-dependent alcohol dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration

Abstract

A new NAD-dependent alcohol dehydrogenase isolated from a Pseudomonas species catalysed the reduction of many acyclic ketones to optically active alcohols with very high enantioselectivity (90 to >98% enantiomeric excess); the stereochemical course of the reduction was determined to be the transfer of the pro-(R) hydrogen from NADH to the Si face of the carbonyl group, a process different from that for other known alcohol dehydrogenases.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1990, 677-679

A new NAD-dependent alcohol dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration

G. Shen, Y. Wang, C. Bradshaw and C. Wong, J. Chem. Soc., Chem. Commun., 1990, 677 DOI: 10.1039/C39900000677

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