The 3,5,6-trisdeoxy derivative of myo-Inositol 1-monophosphate, (1S)-phosphoryloxy-(2R,4S)-dihydroxycyclohexane [(–)-(1)], derived from the parent substrate by a strategy of hydroxy deletion, has been synthesised and shown to be the most potent inhibitor of Inositol monophosphatase yet identified.
R. Baker, P. D. Leeson, N. J. Liverton and J. J. Kulagowski, J. Chem. Soc., Chem. Commun., 1990, 462 DOI: 10.1039/C39900000462
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