Isolation and structure determination of a novel phorbol derivative in an intramolecular diester macrolide
Abstract
Three proteinkinase C-agonizing macrolides, formed by esterification of the novel phorbol derivative 11,18-dehydro-4,12-dideoxy-16-hydroxyphorbol with dicarboxylic acids, that differ only in the state of oxidation of a phenyl residue, were isolated from the dried leaves of Pycnocoma cornuta Muell. (Euphorbiaceae), and their structures were determined by n.m.r. studies.