A one-step highly stereocontrolled synthesis of (–)- and (+)-hexahydrocannabinol and related compounds
Abstract
The title compounds have been prepared in high optical and diastereoisomeric purity by diethylaluminium chloride-assisted condensation of suitable phenols with (R)-(+)- or (S)-(–)-citronellal; the X-ray crystal structure of a hexahydrocannabinol analogue is reported.