The enzyme isopenicillin N synthetase is able to convert directly the dipeptides, phenoxyacetylcysteinylvaline and phenylacetylcysteinylvaline into penicillin V and G respectively; these are however very slow compared with substrates of the α-aminoadipoyl or adipoylcysteinylvaline type.
J. E. Baldwin, E. P. Abraham, G. L. Burge and H. Ting, J. Chem. Soc., Chem. Commun., 1985, 1808 DOI: 10.1039/C39850001808
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