Preparations of the enzyme isopenicillin N synthetase from Cephalosporium acremonium convert the modified substrate (L-α-amino-δ-adipyl)-L-cysteinyl-D-(α-aminobutyrate) into both penam and cepham products, which have been isolated and their structures established.
J. E. Baldwin, E. P. Abraham, R. M. Adlington, B. Chakravarti, A. E. Derome, J. A. Murphy, L. D. Field, N. B. Green, H. Ting and J. J. Usher, J. Chem. Soc., Chem. Commun., 1983, 1317 DOI: 10.1039/C39830001317
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