The reduction of steroid 17-ketones by a chiral hydrosilane–rhodium–(–)(2S,3S)-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane reagent allows greater stereoselectivity of 17α-alcohol formation than is obtained by other methods.
G. Göndös and J. C. Orr, J. Chem. Soc., Chem. Commun., 1982, 1238 DOI: 10.1039/C39820001238
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