The reactivity of 2-bromo-1-phenylethanone (phenacyl bromide) toward nucleophilic species
Abstract
A comparison of second-order rate constants for reactions of 2-bromo-1-phenylethanone (phenacyl bromide) and methyl iodide with various nucleophiles in acetonitrile at 25·0 °C reveals that the rate enhancement due to the carbonyl group in the position adjacent to the reacting carbon atom in alkyl halides is not a general effect but is very dependent upon the nucleophile.