Amino-acids and peptides. Part 19. Conformational studies of the monamycins, a family of cyclohexadepsipeptide antibiotics
Abstract
Evidence derived largely from studies of monamycins D1 and H1 in solution using 1H n.m.r., 13C n.m.r., and i.r. spectroscopy supports a single conformation (Figure 6) for each congener. It incorporates a β-loop with hydrogen bonding of the NH groups of the Val residue to the carbonyl of the hydroxypiperazic acid residue.