In vitro and in vivo rearrangement of eudesmanes to eremophilanes. Substantiation of Robinson's hypothesis
Abstract
Two further examples of the acid-catalysed rearrangement of eudesmanes to eremophilanes in vitro are revealed; Robinson's suggestion that eremophilanes arise in vivo from eudesmanes via a 1,2 methyl shift has been vindicated by tracer studies with grapefruit.