The nature of the cross-linking of proteins by glutaraldehyde. Part I. Interaction of glutaraldehyde with the amino-groups of 6-aminohexanoic acid and of α-N-acetyl-lysine

Abstract

The products of interaction of glutaraldehyde with 6-aminohexanoic acid and with α-N-acetyl-lysine have been separated and partially purified; studies of the most highly purified fraction are indicative of the formation of 1,3,4,5-tetrasubstituted pyridinium salts, such as (II), analogous to desmosine. It is suggested that similar structures are present in the cross-linked products formed by the action of glutaraldehyde on proteins.