Studies concerning the antibiotic actinonin. Part VI. Synthesis of structural analogues of actinonin by dicyclohexylcarbodi-imide coupling reactions

Abstract

The coupling of amino-amides (I) with monoalkyl esters (V) of dicarboxylic acids has been investigated as a route for the specific synthesis of structural analogues (II) and (III) of actinonin (XVII). Methods for the synthesis of the isomers (X) and (XI) have been developed, but their coupling with amino-amides (I) by use of dicyclohexylcarbodi-imide is not specific.