Cyclisation of (N-acetyldidehydrophenylalanyl)sarcosine with acetic anhydride at 75° has furnished the hitherto unknown 4-acetyl-3-trans-benzylidene-1-methylpiperazine-2,5-dione (IV), which readily undergoes deacetylation on treatment with morpholine.
S. Rajappa and B. G. Advani, J. Chem. Soc., Perkin Trans. 1, 1975, 349 DOI: 10.1039/P19750000349
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