Dehydrative cyclization of 5-nitro-6-(N-substituted-anilino)uracils with concentrated sulphuric acid gave the corresponding flavin 5-oxides, which were converted into the respective flavins; autoxidation of 5-amino-6-(N-substituted-anilino)uracils also gave the flavins.
Y. Sakuma, T. Nagamatsu and F. Yoneda, J. Chem. Soc., Chem. Commun., 1975, 977 DOI: 10.1039/C39750000977
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