Crystal and molecular structure of 4′-(acridin-9-ylamino)methanesulphonanilide hydrochloride, a compound showing antileukemic activity

Abstract

The title compound (VI) has antileukemic properties. An X-ray analysis shows it to be triclinic, a= 14·074(1), b= 6·864(1), c= 10·166(1)Å, α= 105·40(3), β= 101·60(2), γ= 86·07(3)°, Z= 2, space group P. The structure was solved by Patterson and Fourier methods. Refinement of 2070 diffractometer data reduced the R factor to 0·046. The acridine ring is slightly non-planar and the phenyl ring makes an angle of 77° with it. This latter appears to be a feature of the molecule rather than a crystal-packing requirement.