The rate of the reaction between hydrogen peroxide and cysteine or cysteamine is proportional to [H2O2] and [NH3+CHXCH2S–](X = H or CO2–) consistent with nucleophilic attack by the thiolate ions on peroxide oxygen. The rate decreases at higher pH where loss of the NH3+ proton occurs, and it is suggested that hydrogen bonding between this group and hydrogen peroxide facilitates the reaction.
J. P. Barton, J. E. Packer and R. J. Sims, J. Chem. Soc., Perkin Trans. 2, 1973, 1547 DOI: 10.1039/P29730001547
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