Constituents of Annona coriacea. The structure of a new diterpenoid

Abstract

A new diterpenoid, 3,17-epoxy-3α-hydroxy-13-hydroxyacetyl-13-methylpodocarp-7-en-16,6β-olactone (1), has been isolated from Annona coriacea; the structural assignment is based on chemical and spectral evidence and is confirmed by conversion of the diterpenoid (1) into (–)-13,13-dimethylpodocarp-7-ene. This correlation indicates the absolute stereochemistry of (I) except for the configuration at C-13 which remains undefined.