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Issue 5, 2015
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Combination of Ru(II) complexes and light: new frontiers in cancer therapy

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Abstract

The synergistic action of light, oxygen and a photosensitizer (PS) has found applications for decades in medicine under the name of photodynamic therapy (PDT) for the treatment of skin diseases and, more recently, for the treatment of cancer. However, of the thirteen PSs currently approved for the treatment of cancer over more than 10 countries, only two contain a metal ion. This fact is rather surprising considering that nowadays around 50% of conventional chemotherapies involve the use of cisplatin and other platinum-containing drugs. In this perspective article, we review the opportunities brought by the use of Ru(II) complexes as PSs in PDT. In addition, we also present the recent achievements in the application of Ru(II) complexes in photoactivated chemotherapy (PACT). In this strategy, the presence of oxygen is not required to achieve cell toxicity. This is of significance since tumors are generally hypoxic. Importantly, this perspective article focuses particularly on the Ru(II) complexes for which an in vitro biological evaluation has been performed and the mechanism of action (partially) unveiled.

Graphical abstract: Combination of Ru(ii) complexes and light: new frontiers in cancer therapy

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Publication details

The article was received on 04 Dec 2014, accepted on 13 Jan 2015 and first published on 13 Jan 2015


Article type: Perspective
DOI: 10.1039/C4SC03759F
Citation: Chem. Sci., 2015,6, 2660-2686
  • Open access: Creative Commons BY license
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    Combination of Ru(II) complexes and light: new frontiers in cancer therapy

    C. Mari, V. Pierroz, S. Ferrari and G. Gasser, Chem. Sci., 2015, 6, 2660
    DOI: 10.1039/C4SC03759F

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      [Original citation] - Published by The Royal Society of Chemistry.

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