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Issue 10, 2015
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Photodynamic therapy (PDT) of cancer: from local to systemic treatment

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Abstract

Photodynamic therapy (PDT) requires a medical device, a photosensitizing drug and adequate use of both to trigger biological mechanisms that can rapidly destroy the primary tumour and provide long-lasting protection against metastasis. We present a multidisciplinary view of the issues raised by the development of PDT. We show how spectroscopy, photophysics, photochemistry and pharmacokinetics of photosensitizers determine the mechanism of cell death and clinical protocols. Various examples of combinations with chemotherapies and immunotherapies illustrate the opportunities to potentiate the outcome of PDT. Particular emphasis is given to the mechanisms that can be exploited to establish PDT as a systemic treatment of solid tumours and metastatic disease.

Graphical abstract: Photodynamic therapy (PDT) of cancer: from local to systemic treatment

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Publication details

The article was received on 31 Mar 2015, accepted on 06 Jul 2015 and first published on 10 Jul 2015


Article type: Perspective
DOI: 10.1039/C5PP00132C
Citation: Photochem. Photobiol. Sci., 2015,14, 1765-1780
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    Photodynamic therapy (PDT) of cancer: from local to systemic treatment

    J. M. Dąbrowski and L. G. Arnaut, Photochem. Photobiol. Sci., 2015, 14, 1765
    DOI: 10.1039/C5PP00132C

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