Jump to main content
Jump to site search

Issue 8, 2015
Previous Article Next Article

Resistance in antimicrobial photodynamic inactivation of bacteria

Author affiliations

Abstract

Antibiotics have increasingly lost their impact to kill bacteria efficiently during the last 10 years. The emergence and dissemination of superbugs with resistance to multiple antibiotic classes have occurred among Gram-positive and Gram-negative strains including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter strains. These six superbugs can “escape” more or less any single kind of antibiotic treatment. That means bacteria are very good at developing resistance against antibiotics in a short time. One new approach is called photodynamic antimicrobial chemotherapy (PACT) which already has demonstrated an efficient antimicrobial efficacy among multi-resistant bacteria. Until now it has been questionable if bacteria can develop resistance against PACT. This perspective summarises the current knowledge about the susceptibility of bacteria towards oxidative stress and sheds some light on possible strategies of the development of photodynamic inactivation of bacteria (PACT)-induced oxidative stress resistance by bacteria.

Graphical abstract: Resistance in antimicrobial photodynamic inactivation of bacteria

Back to tab navigation

Publication details

The article was received on 26 Jan 2015, accepted on 16 May 2015 and first published on 22 Jun 2015


Article type: Perspective
DOI: 10.1039/C5PP00037H
Citation: Photochem. Photobiol. Sci., 2015,14, 1518-1526
  • Open access: Creative Commons BY license
  •   Request permissions

    Resistance in antimicrobial photodynamic inactivation of bacteria

    T. Maisch, Photochem. Photobiol. Sci., 2015, 14, 1518
    DOI: 10.1039/C5PP00037H

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements