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Issue 37, 2015
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Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

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Abstract

The reactions of organic azides and alkynes catalysed by copper species represent the prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed azide–alkyne cycloaddition), discovered in 2002, has been expanded since then to become an excellent tool in organic synthesis. In this contribution the recent results described in the literature since 2010 are reviewed, classified according to the nature of the catalyst precursor: copper(I) or copper(II) salts or complexes, metallic or nano-particulated copper and several solid-supported copper systems.

Graphical abstract: Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

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Publication details

The article was received on 16 Jul 2015, accepted on 31 Jul 2015 and first published on 31 Jul 2015


Article type: Review Article
DOI: 10.1039/C5OB01457C
Citation: Org. Biomol. Chem., 2015,13, 9528-9550
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    Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

    E. Haldón, M. C. Nicasio and P. J. Pérez, Org. Biomol. Chem., 2015, 13, 9528
    DOI: 10.1039/C5OB01457C

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