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Issue 32, 2015
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Morita–Baylis–Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation

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Abstract

Lewis base-promoted annulation reactions with MBHADs have emerged as a key platform for the construction of functionalized carbo- and heterocycles. MBHADs, which are economical and readily available, exert diverse and amazing reactivity when reacted with a wide range of electrophiles. A variety of carbo- and heterocycles, most of which are predominant in natural products and pharmaceuticals, could be constructed with high efficiency. This tutorial review will describe these annulation reactions, with a special emphasis on recent work regarding diverse reactivities of MBHADs.

Graphical abstract: Morita–Baylis–Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation

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Publication details

The article was received on 29 Apr 2015, accepted on 18 Jun 2015 and first published on 18 Jun 2015


Article type: Review Article
DOI: 10.1039/C5OB00865D
Citation: Org. Biomol. Chem., 2015,13, 8578-8595
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    Morita–Baylis–Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation

    P. Xie and Y. Huang, Org. Biomol. Chem., 2015, 13, 8578
    DOI: 10.1039/C5OB00865D

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