Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 8, 2016
Previous Article Next Article

The evolution of genome mining in microbes – a review

Author affiliations

Abstract

Covering: 2006 to 2016

The computational mining of genomes has become an important part in the discovery of novel natural products as drug leads. Thousands of bacterial genome sequences are publically available these days containing an even larger number and diversity of secondary metabolite gene clusters that await linkage to their encoded natural products. With the development of high-throughput sequencing methods and the wealth of DNA data available, a variety of genome mining methods and tools have been developed to guide discovery and characterisation of these compounds. This article reviews the development of these computational approaches during the last decade and shows how the revolution of next generation sequencing methods has led to an evolution of various genome mining approaches, techniques and tools. After a short introduction and brief overview of important milestones, this article will focus on the different approaches of mining genomes for secondary metabolites, from detecting biosynthetic genes to resistance based methods and “evo-mining” strategies including a short evaluation of the impact of the development of genome mining methods and tools on the field of natural products and microbial ecology.

Graphical abstract: The evolution of genome mining in microbes – a review

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 29 Feb 2016 and first published on 08 Jun 2016


Article type: Review Article
DOI: 10.1039/C6NP00025H
Citation: Nat. Prod. Rep., 2016,33, 988-1005
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    The evolution of genome mining in microbes – a review

    N. Ziemert, M. Alanjary and T. Weber, Nat. Prod. Rep., 2016, 33, 988
    DOI: 10.1039/C6NP00025H

Search articles by author