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Issue 12, 2016
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Heterogeneous catalytic approaches in C–H activation reactions

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Abstract

Despite the undisputed advances and progress in metal-catalyzed C–H functionalizations, this atom-economical approach had thus far largely been developed with the aid of various metal catalysts that were operative in a homogeneous fashion. While thereby major progress was accomplished, these catalytic systems featured notable disadvantages, such as low catalyst recyclability. This review summarizes the development of user-friendly, recyclable and easily separable heterogeneous catalysts for C–H activation. This strategy was characterized by a remarkably broad substrate scope, considerable levels of chemo- and site-selectivities and proved applicable to C–C as well as C–heteroatom formation processes. Thus, recyclable catalysts were established for arylations, hydroarylations, alkenylations, acylations, nitrogenations, oxygenations, or halogenations, among others. The rapid recent progress in selective heterogeneous C–H functionalizations during the last decade until December 2015 is reviewed.

Graphical abstract: Heterogeneous catalytic approaches in C–H activation reactions

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Publication details

The article was received on 09 Feb 2016, accepted on 10 Mar 2016 and first published on 10 Mar 2016


Article type: Critical Review
DOI: 10.1039/C6GC00385K
Citation: Green Chem., 2016,18, 3471-3493
  • Open access: Creative Commons BY license
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    Heterogeneous catalytic approaches in C–H activation reactions

    S. Santoro, S. I. Kozhushkov, L. Ackermann and L. Vaccaro, Green Chem., 2016, 18, 3471
    DOI: 10.1039/C6GC00385K

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