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Volume 179, 2015
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Urea homogeneous nucleation mechanism is solvent dependent

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Abstract

The composition of the mother phase plays a primary role in crystallization processes, affecting both crystal nucleation and growth. In this work, the influence of solvents on urea nucleation has been investigated by means of enhanced sampling molecular dynamics simulations. We find that, depending on the solvent, the nucleation process can either follow a single-step or a two-step mechanism. While in methanol and ethanol a single-step nucleation process is favored, in acetonitrile a two-step process emerges as the most likely nucleation pathway. We also find that solvents have a minor impact on polymorphic transitions in the early stages of urea nucleation. The impact of finite size effects on the free energy surfaces is systematically considered and discussed in relation to the simulation setup.

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Publication details

The article was received on 25 Nov 2014, accepted on 09 Jan 2015 and first published on 09 Jan 2015


Article type: Paper
DOI: 10.1039/C4FD00235K
Author version available: Download Author version (PDF)
Citation: Faraday Discuss., 2015,179, 291-307
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    Urea homogeneous nucleation mechanism is solvent dependent

    M. Salvalaglio, M. Mazzotti and M. Parrinello, Faraday Discuss., 2015, 179, 291
    DOI: 10.1039/C4FD00235K

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