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Issue 88, 2015
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A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

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Abstract

In this report we present a polyketal, termed pADK, which has adamantane groups embedded in its backbone, and degrades into neutral excretable compounds. pADK was synthesized via click chemistry and had a MW of 49 472 and a PDI of 1.74. We demonstrate here that pADK can increase the transfection efficiency of CD1800 (PEI of 1800 modified β-cyclodextrin) 60 fold, yet cause no increase in toxicity.

Graphical abstract: A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

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Publication details

The article was received on 25 Jun 2015, accepted on 26 Aug 2015 and first published on 26 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC05242D
Citation: Chem. Commun., 2015,51, 15956-15959
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    A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

    S. Maity, P. Choudhary, M. Manjunath, A. Kulkarni and N. Murthy, Chem. Commun., 2015, 51, 15956
    DOI: 10.1039/C5CC05242D

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