Issue 9, 2006
From the journal:

Chemical Communications

Use of streptomycin for precipitation and detection of proteinase K resistant prion protein (PrPsc) in biological samples

Aly Moussa,*a   Anthony W. Coleman,b   Anna Bencsik,a   Edwige Leclere,c   Florent Perret,b   Ambroise Martind  and  Hervé Perronc  

* Corresponding authors

a Agence Française de Sécurité Sanitaire des Aliments, Site de Lyon, France
E-mail: moussa69@club-internet.fr
Fax: 33 478619145
Tel: 33 617460952

b Institut de Biologie et Chimie de Protéines, CNRS UMR 5086, Lyon, France

c BioMérieux Advanced Technology Unit, R&D Neurological Diseases, Chemin de L'Orme, Marcy L'Etoile, France

d Agence Française de Sécurité Sanitaire des Aliments, DG, Maisons-Alfort, France

Abstract

The ability of streptomycin to form multimolecular aggregates with pathogenic prion proteins and their recovery by precipitation via a low-speed centrifugation step has been demonstrated; these novel properties of streptomycin make it a useful substance that increases the sensitivity of laboratory diagnostic techniques for prion infections in man and animals

Graphical abstract: Use of streptomycin for precipitation and detection of proteinase K resistant prion protein (PrPsc) in biological samples

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B516965H
Article type
Communication
Submitted
24 Nov 2005
Accepted
06 Jan 2006
First published
20 Jan 2006

Chem. Commun., 2006, 973-975

Permissions

Request permissions

Use of streptomycin for precipitation and detection of proteinase K resistant prion protein (PrPsc) in biological samples

A. Moussa, A. W. Coleman, A. Bencsik, E. Leclere, F. Perret, A. Martin and H. Perron, Chem. Commun., 2006, 973 DOI: 10.1039/B516965H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements