New nanomaterials for the improvement of psoriatic lesions

Maria Crisan; Luminita David; Bianca Moldovan; Adriana Vulcu; Simina Dreve; Maria Perde-Schrepler; Corina Tatomir; Adriana Gabriela Filip; Pompei Bolfa; Marcela Achim; Ioana Chiorean; Irina Kacso; Camelia Berghian Grosan; Liliana Olenic

doi:10.1039/C3TB20476F

New nanomaterials for the improvement of psoriatic lesions†

Maria Crisan,^a Luminita David,^b Bianca Moldovan,^b Adriana Vulcu,^c Simina Dreve,^c Maria Perde-Schrepler,^d Corina Tatomir,^d Adriana Gabriela Filip,^e Pompei Bolfa,^f Marcela Achim,^g Ioana Chiorean,*^h Irina Kacso,^c Camelia Berghian Grosan^c and Liliana Olenic*^c

Author affiliations

* Corresponding authors

^a Histology Department, Iuliu Haţieganu University of Medicine and Pharmacy, Emil Isaac Street 13, 400023 Cluj-Napoca, Romania
E-mail: maria.crisan@umfcluj.ro
Fax: +40 264 592394
Tel: +40 264 406843

^b Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos Street, Cluj-Napoca, Romania
E-mail: muntean@chem.ubbcluj.ro, bianca@chem.ubbcluj.ro
Fax: +40 264 590818
Tel: +40 264 593833

^c National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Street, Cluj-Napoca, Romania
E-mail: adriana.vulcu@itim-cj.ro, simina.dreve@itim-cj.ro, irina.kacso@itim-cj.ro, camelia.grosan@itim-cj.ro, liliana.olenic@itim-cj.ro
Fax: +40 264 420042
Tel: +40 264 584037

^d “Ion Chiricuţă” Oncology Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania
E-mail: mperde@iocn.ro, coratat@yahoo.com
Fax: +40 264 439260
Tel: +40 264 598361

^e University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj Napoca, Department of Physiology, 1-3 Clinicilor Street, Cluj-Napoca, Romania
E-mail: gabriela.filip@umfcluj.ro
Fax: +40-264-597257
Tel: +40-264-598575

^f Department of Morphopathology, University of Agricultural Sciences and Veterinary Medicine, 3-5 Calea Manastur Str., Cluj-Napoca, Romania
E-mail: pompeibolfa@gmail.com
Fax: +40 264 593792
Tel: +40 264 596384

^g Departments of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hatieganu University of Medicine and Pharmacy, 12 Ion Creanga St., Cluj-Napoca, Romania
E-mail: machim@umfcluj.ro
Fax: +40 364 815170
Tel: +40 264 595770

^h Faculty of Mathematics and Informatics, Babeş-Bolyai University, Kogălniceanu Street, 1, 400023 Cluj-Napoca, Romania
E-mail: ioana@math.ubbcluj.ro
Fax: +40 264 591906
Tel: +40 264 405300

Abstract

The main purpose of the present paper is to emphasize the non-invasive effect of some new prepared nanomaterials on skin diseases (psoriasis) together with the procedures to obtain them. These new materials are based on gold nanoparticles and natural compounds extracted from native plants of the Adoxaceae family (European cranberrybush – Viburnum opulus L. and European black elderberry – Sambucus nigra L.) and possess a known anti-inflammatory activity mainly due to their high content of anthocyanins and other polyphenols. The nanomaterials were characterized by transmission electron microscopy (TEM), UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX) and thermogravimetric analysis (TGA). Studies in vivo and in vitro were made in order to determine the toxicity of the products. Based on the obtained nanomaterials, specific dermatological creams were prepared. Their effect on psoriatic lesions, in comparison with the hydrocortisone creams, was studied.

Journal of Materials Chemistry B

New nanomaterials for the improvement of psoriatic lesions†

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New nanomaterials for the improvement of psoriatic lesions

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