Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods

Abstract

In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe₃O₄–PVA@SH, the step-by-step method and the one-pot method. The loading and release properties of the compound were measured. The results show that the Fe₃O₄–PVA@SH prepared using both methods exhibited excellent drug delivery properties in an environment that simulates human body fluid (pH 7.2) and a lysosomal in vitro simulation (pH 4.7). In applications such as drug delivery, magnetic targeted drug carriers prepared by both methods demonstrated superparamagnetism, high fat solubility, high hydroxyl content, and good water solubility.