Issue 69, 2021

Reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3 as a reductant

Abstract

Herein, we report the first example of efficient reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3 as a catalyst and a reductant under mild conditions, affording various tertiary and secondary amines in excellent yields. A mechanistic study indicates that BH3N(C2H5)3 plays a dual function role of promoting imine and iminium formation and serving as a reductant in reductive amination.

Graphical abstract: Reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3 as a reductant

Supplementary files

Article information

Article type
Communication
Submitted
19 May 2021
Accepted
28 Jul 2021
First published
29 Jul 2021

Chem. Commun., 2021,57, 8588-8591

Reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3 as a reductant

Q. Zou, F. Liu, T. Zhao and X. Hu, Chem. Commun., 2021, 57, 8588 DOI: 10.1039/D1CC02618F

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