Issue 35, 2020

Covalent organic framework membrane for size selective release of small molecules and peptide in vitro

Abstract

The ability to control small drug release is crucial in biomedicine, especially for inhibiting the side effects of drugs, but it is still challenging. Herein, to mimic the controlled release of drugs, the release of organic molecules, e.g., small organic dyes and peptides, through Covalent Organic Framework (COF) membranes with ordered nanoscale pores has been investigated, showing constant zero-order release behaviours. Meanwhile, biological assessments show the good biocompatibility of the COF membrane-based release system, and the high stability of the COF membrane was manifested by the long-term release of small molecules in aqueous media.

Graphical abstract: Covalent organic framework membrane for size selective release of small molecules and peptide in vitro

Supplementary files

Article information

Article type
Communication
Submitted
04 Jun 2020
Accepted
13 Aug 2020
First published
13 Aug 2020

J. Mater. Chem. B, 2020,8, 7899-7903

Covalent organic framework membrane for size selective release of small molecules and peptide in vitro

H. Rezvani Alanagh, I. Rostami, M. Taleb, X. Gao, Y. Zhang, A. M. Khattak, X. He, L. Li and Z. Tang, J. Mater. Chem. B, 2020, 8, 7899 DOI: 10.1039/D0TB01416H

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