Issue 28, 2020, Issue in Progress

Induction of ADCC by a folic acid–mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells

Abstract

We developed conjugates between monoclonal antibody (mAb) and folic acid (FA) by using a tryptophan (Trp)-selective reaction, which yields relatively homogenous products compared to conventional methods. The obtained mAb–FA conjugates showed significant cellular cytotoxicity toward folate receptor-expressing cancer cells, demonstrating that the conjugates retained the Fc region's original function.

Graphical abstract: Induction of ADCC by a folic acid–mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells

Supplementary files

Article information

Article type
Paper
Submitted
18 Mar 2020
Accepted
16 Apr 2020
First published
29 Apr 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 16727-16731

Induction of ADCC by a folic acid–mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells

H. Tagawa, K. Maruyama, K. Sasaki, N. Konoue, A. Kishimura, M. Kanai, T. Mori, K. Oisaki and Y. Katayama, RSC Adv., 2020, 10, 16727 DOI: 10.1039/D0RA03291C

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